27 Y.O Chemical Engineer- To Buy a house (Houston, Texas)?

This post is for my brother, we live in Houston. He is considering buying a house. He has no debt, single and he has about 75k saved up and about 145k in his stocks/401k/ Roth IRA. He makes 125k a year at his company and an extra 10k if he gets a bonus so about 135k a year. He is thinking of buying a new build or fairly new house in our area (Pearland, TX) but the prices for a 4 bedroom (what he wants) is at least 360k, with the interest rates and property taxes if he puts 20% down (72k) he will be paying about 3k a month. After taxes and 401k (he maxes it out) he makes 6k a month, so half of his earnings would go towards the house. He drives a Toyota Camry so its reliable and its paid off

Anyways just want to get peoples thoughts. Its crazy how expensive things have gotten.